Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats
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چکیده
منابع مشابه
Baclofen facilitates sleep, neuroplasticity, and recovery after stroke in rats
OBJECTIVE Sleep disruption in the acute phase after stroke has detrimental effects on recovery in both humans and animals. Conversely, the effect of sleep promotion remains unclear. Baclofen (Bac) is a known non-rapid eye movement (NREM) sleep-promoting drug in both humans and animals. The aim of this study was to investigate the effect of Bac on stroke recovery in a rat model of focal cerebral...
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PURPOSE Limb remote ischemic per-conditioning or post-conditioning has been shown to be neuroprotective after cerebral ischemic stroke. However, the effect of combining remote per-conditioning with post-conditioning on ischemic/reperfusion injury as well as the underlying mechanisms are largely unexplored. METHODS Here, adult male Sprague Dawley rats were subjected to middle cerebral artery o...
متن کاملEffects of Aerobic Training on Caspase-3 Expression and Apoptosis in Hippocampus of Rats after Brain Ischemic Stroke
Introduction: Although exercise is an effective strategy for preventing and treating stroke, the extent of this effect seems to depend on when exercise begins. Apoptosis plays a critical role after stroke. However, it is unclear whether early exercise inhibits apoptosis after stroke? The aim of this study was to determine the effect of eight weeks of early aerobic training after stroke inductio...
متن کاملUnusual Recovery of Aphasia in a Polyglot Iranian Patient after Ischemic Stroke
Introduction: Aphasia is a language disorder resulting from a lesion in the cerebral cortex. In this case report, we present a polyglot patient who recovered from aphasia by speaking his newly active learned language Case Report: A 69 years old male referred with acute onset right hemiparesis and global aphasia. After imaging, he treated with 75 mg r-TPA (0.9 mg/kg). After the fourth day of ...
متن کاملVascularization pattern after ischemic stroke is different in control versus diabetic rats: relevance to stroke recovery.
BACKGROUND AND PURPOSE Pre-existing diabetes mellitus worsens brain functionality in ischemic stroke. We have previously shown that type 2 diabetic rats exhibit enhanced dysfunctional cerebral neovascularization and when these rats are subjected to cerebral ischemic reperfusion injury develop hemorrhagic transformation and greater neurological deficits. However, our knowledge of vascular and fu...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2013
ISSN: 0022-3042
DOI: 10.1111/jnc.12342